Effect of lifestyle change on weight

# How does a lifestyle change affect you? Lifestyle encompasses all areas of daily living such as exercise or eating habits, consumption style, leisure behavior, media use and socializing as well as political thinking, values, attitudes and much more. A long-term change in lifestyle is therefore accompanied by numerous changes, both positive and negative, and also affects body weight. A healthy diet and regular exercise not only have an effect on body weight, but also influence physical health and mental well-being. > ## Ready for a lifestyle change? > > How effective a lifestyle change can be depends on genetics on the one hand, and consistency, discipline and perseverance on the other. > Genetic predisposition says something about the tolerance of food and indicates whether, for example, fat burning works efficiently or whether excess energy tends to be stored. > This means that weight gain and weight loss can also be genetically influenced. This explains why some people seem to stay slim with ease, while others have constant weight problems despite great efforts. # Other factors Regardless of your genetic predisposition, your body weight can also be influenced by other factors such as stress, social environment, emotional stability, sleep quality and much more. # What does genetics have to do with it? We are investigating a gene that reveals the effect of lifestyle changes on weight: The PPARD gene (peroxisome proliferator-activated receptor delt gene) carries the blueprint for a so-called PPAR receptor (peroxisome proliferator-activated receptor) in the cells. PPAR receptors are localized in the cell nucleus and influence a large number of genes, which in turn influence lipid metabolism, glucose metabolism and inflammatory reactions. The PPARD gene allows conclusions to be drawn about the effect of lifestyle changes on body composition. Certain genetic variations in the PPARD gene can therefore influence fat burning, metabolism and insulin sensitivity. For example, carriers of this gene may have lower fat burning and an increased tendency to store fat. This often goes hand in hand with more rapid weight gain and even overweight and obesity. - Variant rs1053049 of the PPARD gene: Genotypes C/C and C/T respond less efficiently to lifestyle changes and tend to increase fat storage and reduce fat burning. In many cases, this combination leads to more rapid weight gain, including overweight and obesity. Carriers of this variant generally tend to develop insulin resistance, in the course of which the body cells react only very cautiously or not at all to the hormone insulin. This is usually the precursor to type 2 diabetes. - Variant rs2267668 of the PPARD gene: Genotypes A/G and G/G respond less efficiently to lifestyle changes and tend to increase fat storage and reduce fat burning. In many cases, this combination leads to more rapid weight gain, including overweight and obesity. Carriers of this variant generally tend to develop insulin resistance, in the course of which the body cells react only very cautiously or not at all to the hormone insulin. This is usually the precursor to type 2 diabetes. The positive side: this variant shows a good effect of consistent aerobic training (aerobic area; endurance and coordination) on physical fitness.